Distinct and Overlapping Effector Functions of Expanded Human CD4+, CD8α+ and CD4-CD8α- Invariant Natural Killer T Cells

@inproceedings{OReilly2011DistinctAO,
  title={Distinct and Overlapping Effector Functions of Expanded Human CD4+, CD8α+ and CD4-CD8α- Invariant Natural Killer T Cells},
  author={Vincent P O'Reilly and Shijuan Grace Zeng and Gabriel Bricard and Ann Atzberger and Andrew E. Hogan and J. J. Jackson and Conleth Feighery and Steven A. Porcelli and Derek G. Doherty},
  booktitle={PloS one},
  year={2011}
}
CD1d-restricted invariant natural killer T (iNKT) cells have diverse immune stimulatory/regulatory activities through their ability to release cytokines and to kill or transactivate other cells. Activation of iNKT cells can protect against multiple diseases in mice but clinical trials in humans have had limited impact. Clinical studies to date have targeted polyclonal mixtures of iNKT cells and we proposed that their subset compositions will influence therapeutic outcomes. We sorted and… CONTINUE READING
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