Distinct actions of benzene and its metabolites on nitric oxide production by bone marrow leukocytes.

@article{Laskin1995DistinctAO,
  title={Distinct actions of benzene and its metabolites on nitric oxide production by bone marrow leukocytes.},
  author={Jeffrey D Laskin and Niranjan S. Rao and C J Punjabi and Debra L. Laskin and R Synder},
  journal={Journal of leukocyte biology},
  year={1995},
  volume={57 3},
  pages={422-6}
}
Benzene is a widely used industrial solvent known to cause bone marrow depression. This is associated with increased production of reactive oxygen metabolites and nitric oxide by bone marrow phagocytes, which have been implicated in hematotoxicity. Benzene metabolism to phenolic intermediates appears to be an important factor in bone marrow toxicity. In the present studies, we compared the effects of benzene and several of its metabolites on nitric oxide production by murine bone marrow… CONTINUE READING

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