Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression

@article{Knowland2017DistinctVP,
  title={Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression},
  author={Daniel Knowland and Varoth Lilascharoen and Christopher Pham Pacia and Sora Shin and Eric Hou-Jen Wang and Byung Kook Lim},
  journal={Cell},
  year={2017},
  volume={170},
  pages={284-297.e18}
}
Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depression and how they adapt in response to stress has not been addressed. We identify two discrete circuits of parvalbumin-positive (PV) neurons in the ventral pallidum (VP… CONTINUE READING
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