Distinct Treatment Outcomes of Antiparasitic Therapy in Trypanosoma cruzi-Infected Children Is Associated With Early Changes in Cytokines, Chemokines, and T-Cell Phenotypes

@article{Albareda2018DistinctTO,
  title={Distinct Treatment Outcomes of Antiparasitic Therapy in Trypanosoma cruzi-Infected Children Is Associated With Early Changes in Cytokines, Chemokines, and T-Cell Phenotypes},
  author={M. Albareda and M. A. Natale and A. D. de Rissio and M. Fern{\'a}ndez and A. Serjan and M. G. {\'A}lvarez and Gretchen Cooley and Huifeng Shen and R. Viotti and J. Bua and Melisa D. Castro Eiro and M. N{\'u}{\~n}ez and L. Fichera and B. Lococo and K. Scollo and R. Tarleton and S. Laucella},
  journal={Frontiers in Immunology},
  year={2018},
  volume={9}
}
Background: In contrast to adults, Trypanosoma cruzi-infected children have more broadly functional Trypanosoma cruzi-specific T cells, and the total T-cell compartment exhibits fewer signs of immune exhaustion. However, not much is known about the link between immunocompetence and the treatment efficacy for human Chagas disease. Methods: Using cytokine enzyme-linked immunosorbent spot (ELISPOT) polychromatic flow cytometry, cytometric bead assay, multiplex serological assays and quantitative… Expand
8 Citations
The unmet medical need for Trypanosoma cruzi-infected patients: Monitoring the disease status.
  • 2
  • PDF
A flexible, pan-species, multi-antigen platform for the detection and monitoring of SARS-CoV-2-specific antibody responses
  • 2
  • Highly Influenced
  • PDF
WHF IASC Roadmap on Chagas Disease
  • 9
  • PDF

References

SHOWING 1-10 OF 42 REFERENCES
Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.
  • 81
  • PDF
Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease.
  • 185
  • PDF
Chronic Human Infection with Trypanosoma cruzi Drives CD4+ T Cells to Immune Senescence1
  • 76
  • PDF
Assessment of CD8(+) T cell differentiation in Trypanosoma cruzi-infected children.
  • 13
...
1
2
3
4
5
...