Distinct Transcriptional Signatures of Bone Marrow-Derived C57BL/6 and DBA/2 Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes

@inproceedings{Giraud2012DistinctTS,
  title={Distinct Transcriptional Signatures of Bone Marrow-Derived C57BL/6 and DBA/2 Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes},
  author={Emilie Giraud and Herv{\'e} Lecoeur and Guillaume Soubigou and Jean-Yves Copp{\'e}e and Genevi{\`e}ve Milon and Eric Prina and Thierry Lang},
  booktitle={PLoS neglected tropical diseases},
  year={2012}
}
BACKGROUND/OBJECTIVES The inoculation of a low number (10(4)) of L. amazonensis metacyclic promastigotes into the dermis of C57BL/6 and DBA/2 mouse ear pinna results in distinct outcome as assessed by the parasite load values and ear pinna macroscopic features monitored from days 4 to 22-phase 1 and from days 22 to 80/100-phase 2. While in C57BL/6 mice, the… CONTINUE READING