Distinct T cell/renal tubular epithelial cell interactions define differential chemokine production: implications for tubulointerstitial injury in chronic glomerulonephritides.

@article{Kuroiwa2000DistinctTC,
  title={Distinct T cell/renal tubular epithelial cell interactions define differential chemokine production: implications for tubulointerstitial injury in chronic glomerulonephritides.},
  author={Takashi Kuroiwa and Ryan Jon Schlimgen and Gabor G. Illei and Iain B. Mcinnes and Dimitrios T. Boumpas},
  journal={Journal of immunology},
  year={2000},
  volume={164 6},
  pages={3323-9}
}
Chemokines can promote interstitial fibrosis that is, in turn, a strong predictor of renal failure in chronic glomerulonephritides (GN). Resident renal cells, including renal tubular epithelial cells (RTEC), represent a prominent source of chemokine expression. Evaluating those factors responsible for sustained chemokine production by RTEC during GN is therefore crucial. The contribution of interstitial T cells to such expression, and in particular the precise nature of their interactions with… CONTINUE READING

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