Distinct Subcellular Distribution of δ-Opioid Receptor Fused with Various Tags in PC12 Cells

@article{Wang2008DistinctSD,
  title={Distinct Subcellular Distribution of δ-Opioid Receptor Fused with Various Tags in PC12 Cells},
  author={Haibo Wang and Ji-Song Guan and Lan Bao and Xu Zhang},
  journal={Neurochemical Research},
  year={2008},
  volume={33},
  pages={2028-2034}
}
In small dorsal root ganglion neurons, δ-opioid receptors (DORs) have been found to be mainly distributed in the cytoplasm and often associated with the membrane of large dense-core vesicles (LDCVs) that contain neuropeptides. To study the distribution of DORs under various physiological or pharmacological conditions, the receptors fused with different tags are constructed, transfected into cells or animals, and examined with microscopy. In this study, we show that DOR with different tags have… CONTINUE READING