• Corpus ID: 248986744

Distinct Speed and Direction Memories of Migrating Cells Diversify Their Possible Search Strategies

@inproceedings{Shaebani2022DistinctSA,
  title={Distinct Speed and Direction Memories of Migrating Cells Diversify Their Possible Search Strategies},
  author={M. Reza Shaebani and Matthieu Piel and Franziska Lautenschlager},
  year={2022}
}
Migrating cells exhibit various motility patterns, resulting from different migration mechanisms, cell properties, or cell-environment interactions. The complexity of cell dynamics is reflected, e.g., in the diversity of the observed forms of velocity autocorrelation function— that has been widely served as a measure of diffusivity and spreading—. By analyzing the dynamics of migrating dendritic cells in vitro , we disentangle the contributions of direction θ and speed v ( ≡| v | ) to the velocity… 

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References

SHOWING 1-10 OF 51 REFERENCES
Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo
TLDR
Light sheet microscopy of T cells in the larval zebrafish is used as a model system to study motility across large populations of cells over hours in their native context, showing substantial cell-to-cell variability in speed, which persists over timespans of a few hours.
Anomalous dynamics of cell migration
TLDR
By analyzing the trajectories of wild-type and mutated epithelial (transformed Madin–Darby canine kidney) cells, it is shown experimentally that anomalous dynamics characterizes cell migration.
Persistence-Speed Coupling Enhances the Search Efficiency of Migrating Immune Cells.
TLDR
This work finds that the speed and directional persistence of migrating dendritic cells in the authors' in vitro experiments are highly correlated, which enables them to reduce their search time.
Functional Analysis of Spontaneous Cell Movement under Different Physiological Conditions
TLDR
The relation of spontaneous cell movement to cellular physiological function and its relevance to behavioral strategies for cell survival is discussed and a generalized Langevin model is applied to the experimental data.
Non-Gaussianity, population heterogeneity, and transient superdiffusion in the spreading dynamics of amoeboid cells.
TLDR
The current analysis of single-cell motions of the Dictyostelium discoideum amoeboid cells is implemented for quantifying diffusive behaviours in other living-matter systems, in particular, when effects of active transport, non-Gaussian displacements, and heterogeneity of the population are involved in the dynamics.
Three-dimensional cell migration does not follow a random walk
TLDR
This paper introduces and validate a new model of 3D cell migration that takes into account cell heterogeneity and the anisotropic movements induced by local remodeling of the 3D matrix, and reveals the unexpected robust relation between cell speed and persistence of migration over a wide range of matrix densities.
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells
TLDR
CD8+ T-cell behaviour is similar to Lévy strategies reported in organisms ranging from mussels to marine predators and monkeys, and CXCL10 aids T cells in shortening the average time taken to find rare targets.
Fractal reorientation clocks: Linking animal behavior to statistical patterns of search
TLDR
This study explores the potential links between intermittent locomotion, re orientation behavior, and search efficiency and proposes that Lévy intermittence may come from reorientation mechanisms capable of organizing directional persistence on time, and rationalizes that the explicit distinction between scanning and reorientations mechanisms is essential to make accurate statistical inferences from animal search behavior.
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