Distinct Single Amino Acid Replacements in the Control of Virulence Regulator Protein Differentially Impact Streptococcal Pathogenesis

@inproceedings{Horstmann2011DistinctSA,
  title={Distinct Single Amino Acid Replacements in the Control of Virulence Regulator Protein Differentially Impact Streptococcal Pathogenesis},
  author={Nicola Horstmann and Pranoti V Sahasrabhojane and Bryce Suber and Muthiah Kumaraswami and Randall Olsen and Anthony R. Flores and James M. Musser and Richard G Brennan and Samuel A. Shelburne},
  booktitle={PLoS pathogens},
  year={2011}
}
Sequencing of invasive strains of group A streptococci (GAS) has revealed a diverse array of single nucleotide polymorphisms in the gene encoding the control of virulence regulator (CovR) protein. However, there is limited information regarding the molecular mechanisms by which CovR single amino acid replacements impact GAS pathogenesis. The crystal structure of the CovR C-terminal DNA-binding domain was determined to 1.50 Å resolution and revealed a three-stranded β-sheet followed by a winged… CONTINUE READING
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