Distinct Roles of Transcription Factors Brn3a and Brn3b in Controlling the Development, Morphology, and Function of Retinal Ganglion Cells

@article{Badea2009DistinctRO,
  title={Distinct Roles of Transcription Factors Brn3a and Brn3b in Controlling the Development, Morphology, and Function of Retinal Ganglion Cells},
  author={Tudor Constantin Badea and Hugh B. Cahill and Jen Ecker and Samer S Hattar and Jeremy Nathans},
  journal={Neuron},
  year={2009},
  volume={61},
  pages={852-864}
}
Transcriptional regulatory networks that control the morphologic and functional diversity of mammalian neurons are still largely undefined. Here we dissect the roles of the highly homologous POU-domain transcription factors Brn3a and Brn3b in retinal ganglion cell (RGC) development and function using conditional Brn3a and Brn3b alleles that permit the visualization of individual wild-type or mutant cells. We show that Brn3a- and Brn3b-expressing RGCs exhibit overlapping but distinct dendritic… CONTINUE READING
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