Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory

@article{Kim2016DistinctRO,
  title={Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory},
  author={Dohoung Kim and Huijeong Jeong and Juhyeong Lee and Jeong-Wook Ghim and Eun Sil Her and Seung-hee Lee and Min Whan Jung},
  journal={Neuron},
  year={2016},
  volume={92},
  pages={902-915}
}
Inhibitory interneurons are thought to play crucial roles in diverse brain functions. However, roles of different inhibitory interneuron subtypes in working memory remain unclear. We found distinct activity patterns and stimulation effects of two major interneuron subtypes, parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons, in the medial prefrontal cortex of mice performing a spatial working memory task. PV interneurons showed weak target-dependent delay-period activity and were… CONTINUE READING
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