Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes

@inproceedings{Fu2011DistinctRO,
  title={Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes},
  author={Ji-Dong Fu and Stephanie N. Rushing and Deborah K Lieu and Camie W Y Chan and Chi-wing Kong and Lin Geng and Kitchener D. Wilson and Nipavan Chiamvimonvat and Kenneth R. Boheler and Joseph C Wu and Gordon Keller and Roger J. Hajjar and Ronald A. Li},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND MicroRNAs (miRs) negatively regulate transcription and are important determinants of normal heart development and heart failure pathogenesis. Despite the significant knowledge gained in mouse studies, their functional roles in human (h) heart remain elusive. METHODS AND RESULTS We hypothesized that miRs that figure prominently in cardiac differentiation are differentially expressed in differentiating, developing, and terminally mature human cardiomyocytes (CMs). As a first step, we… CONTINUE READING
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