Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

@article{Matsumoto1997DistinctRO,
  title={Distinct Roles of Lymphotoxin α and the Type I Tumor  Necrosis Factor (TNF) Receptor in the Establishment of  Follicular Dendritic Cells from Non–Bone Marrow–derived Cells },
  author={Mitsuru Matsumoto and Yang-Xin Fu and H{\'e}ctor R Molina and Guangming Huang and Jinho Jay Kim and Dori A. Thomas and Moon H. Nahm and David D. Chaplin},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={1997 - 2004}
}
In mice deficient in either lymphotoxin alpha (LT-alpha) or type I tumor necrosis factor receptor (TNFR-I), organized clusters of follicular dendritic cells (FDC) and germinal centers (GC) are absent from the spleen. We investigated the role of LT-alpha and TNFR-I in the establishment of spleen FDC and GC structure by using reciprocal bone marrow (BM) transfer. When LT-alpha-deficient mice were reconstituted with wild-type BM, FDC organization and the ability to form GC were restored… CONTINUE READING

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Lymphotoxin-a (LTa) supports development of splenic follicular structure that is required for IgG responses

  • Fu, Y.-X, +4 authors D. D. Chaplin
  • J. Exp. Med
  • 1997

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