Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine.

@article{Goto2017DistinctRO,
  title={Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine.},
  author={Norihiro Goto and Taro Ueo and Akihisa Fukuda and Kenji Kawada and Yoshiharu Sakai and Hiroyuki Miyoshi and Makoto Mark Taketo and Tsutomu Chiba and Hiroshi Seno},
  journal={Cancer research},
  year={2017},
  volume={77 13},
  pages={3442-3454}
}
Cancer stem cells (CSC) have attracted attention as therapeutic targets; however, CSC-targeting therapy may disrupt normal tissue homeostasis because many CSC molecules are also expressed by normal stem cells (NSC). Here, we demonstrate that NSC-specific and CSC-specific roles of the stem cell transcription factor Hes1 in the intestine enable the feasibility of a specific cancer therapy. Hes1 expression was upregulated in NSCs and intestinal tumors. Lineage-tracing experiments in adult mouse… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
2 Citations
0 References
Similar Papers