Distinct Roles for Secreted Semaphorin Signaling in Spinal Motor Axon Guidance

  title={Distinct Roles for Secreted Semaphorin Signaling in Spinal Motor Axon Guidance},
  author={Andrea B. Huber and Artur Kania and Tracy S. Tran and Chenghua Gu and Natalia V. De Marco Garcia and Ivo Lieberam and Dontais Johnson and Thomas M. Jessell and David D Ginty and Alex L Kolodkin},
Neuropilins, secreted semaphorin coreceptors, are expressed in discrete populations of spinal motor neurons, suggesting they provide critical guidance information for the establishment of functional motor circuitry. We show here that motor axon growth and guidance are impaired in the absence of Sema3A-Npn-1 signaling. Motor axons enter the limb precociously, showing that Sema3A controls the timing of motor axon in-growth to the limb. Lateral motor column (LMC) motor axons within spinal nerves… CONTINUE READING
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