Distinct Roles for Neuropilin1 and Neuropilin2 during Mouse Corneal Innervation

  title={Distinct Roles for Neuropilin1 and Neuropilin2 during Mouse Corneal Innervation},
  author={Chelsey C. McKenna and Ravi P. Munjaal and Peter Y. Lwigale},
  booktitle={PloS one},
Trigeminal sensory innervation of the cornea is critical for protection and synthesis of neuropeptides required for normal vision. Little is known about axon guidance during mammalian corneal innervation. In contrast to the chick where a pericorneal nerve ring forms via Npn/Sema signaling, mouse corneal axons project directly into the presumptive cornea without initial formation of an analogous nerve ring. Here we show that during development of the mouse cornea, Npn1 is strongly expressed by… CONTINUE READING
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