Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress.

@article{Wray2008DistinctRA,
  title={Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress.},
  author={Justin W Wray and Jingmei Liu and Jac A. Nickoloff and Zhiyuan Shen},
  journal={Cancer research},
  year={2008},
  volume={68 8},
  pages={2699-707}
}
RAD51 has critical roles in homologous recombination (HR) repair of DNA double-strand breaks (DSB) and restarting stalled or collapsed replication forks. In yeast, Rad51 function is facilitated by Rad52 and other "mediators." Mammalian cells express RAD52, but BRCA2 may have supplanted RAD52 in mediating RAD51 loading onto ssDNA. BCCIP interacts with BRCA2, and both proteins are important for RAD51 focus formation after ionizing radiation and HR repair of DSBs. Nonetheless, mammalian RAD52… CONTINUE READING
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Mammalian homologous recombination and cancer intervention

  • Z Shen, JA Nickoloff
  • 2007

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