Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex

@article{Tomassy2014DistinctPO,
  title={Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex},
  author={Giulio Srubek Tomassy and Daniel R. Berger and Hsu-hsin Chen and N. Kasthuri and Kenneth Jeffrey Hayworth and Alessandro Vercelli and H. Sebastian Seung and Jeff William Lichtman and Paola Arlotta},
  journal={Science},
  year={2014},
  volume={344},
  pages={319-324}
}
Myelin is a defining feature of the vertebrate nervous system. Variability in the thickness of the myelin envelope is a structural feature affecting the conduction of neuronal signals. Conversely, the distribution of myelinated tracts along the length of axons has been assumed to be uniform. Here, we traced high-throughput electron microscopy reconstructions of single axons of pyramidal neurons in the mouse neocortex and built high-resolution maps of myelination. We find that individual neurons… CONTINUE READING
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