Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes

@inproceedings{Maurer2017DistinctNP,
  title={Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes},
  author={Jana Maurer and Sabrina Hupp and Carolin Bischoff and Christina Foertsch and Tim J Mitchell and Trinad Chakraborty and Asparouh I Iliev},
  booktitle={Toxins},
  year={2017}
}
Cholesterol-dependent cytolysins (CDCs) are protein toxins that originate from Gram-positive bacteria and contribute substantially to their pathogenicity. CDCs bind membrane cholesterol and build prepores and lytic pores. Some effects of the toxins are observed in non-lytic concentrations. Two pathogens, Streptococcus pneumoniae and Listeria monocytogenes, cause fatal bacterial meningitis, and both produce toxins of the CDC family-pneumolysin and listeriolysin O, respectively. It has been… CONTINUE READING
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