Distinct Neurochemical Profiles of Spinocerebellar Ataxias 1, 2, 6, and Cerebellar Multiple System Atrophy

@article{z2010DistinctNP,
  title={Distinct Neurochemical Profiles of Spinocerebellar Ataxias 1, 2, 6, and Cerebellar Multiple System Atrophy},
  author={G{\"u}lin {\"O}z and Isabelle Iltis and Diane Hutter and William Dean Thomas and K. O. Bushara and Christopher M. Gomez},
  journal={The Cerebellum},
  year={2010},
  volume={10},
  pages={208-217}
}
Hereditary and sporadic neurodegenerative ataxias are movement disorders that affect the cerebellum. Robust and objective biomarkers are critical for treatment trials of ataxias. In addition, such biomarkers may help discriminate between ataxia subtypes because these diseases display substantial overlap in clinical presentation and conventional MRI. Profiles of 10–13 neurochemical concentrations obtained in vivo by high field proton magnetic resonance spectroscopy (1H MRS) can potentially… CONTINUE READING
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