Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis.

@article{Blackwell2001DistinctMD,
  title={Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis.},
  author={Leonard J. Blackwell and Keith P Bjornson and Dale J. Allen and Paul Modrich},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 36},
  pages={34339-47}
}
The role of MutS ATPase in mismatch repair is controversial. To clarify further the function of this activity, we have examined adenine nucleotide effects on interactions of Escherichia coli MutS with homoduplex and heteroduplex DNAs. In contrast to previous results with human MutS alpha, we find that a physical block at one end of a linear heteroduplex is sufficient to support stable MutS complex formation in the presence of ATP.Mg(2+). Surface plasmon resonance analysis at low ionic strength… CONTINUE READING
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