Distinct Mitral Valve Proteomic Profiles in Rheumatic Heart Disease and Myxomatous Degeneration

@article{Martins2014DistinctMV,
  title={Distinct Mitral Valve Proteomic Profiles in Rheumatic Heart Disease and Myxomatous Degeneration},
  author={C. Martins and K. S. Santos and F. M. Ferreira and P. Teixeira and P. Pomerantzeff and Carlos M A Brand{\~a}o and R. Sampaio and G. Spina and J. Kalil and L. Guilherme and E. Cunha-Neto},
  journal={Clinical Medicine Insights. Cardiology},
  year={2014},
  volume={8},
  pages={79 - 86}
}
  • C. Martins, K. S. Santos, +8 authors E. Cunha-Neto
  • Published 2014
  • Medicine
  • Clinical Medicine Insights. Cardiology
  • Rheumatic heart disease (RHD) affects heart-valve tissue and is the most serious consequence of group A Streptococcus infection. Myxomatous degeneration (MXD) is the most frequent valvopathy in the western world. In the present work, key protein expression alterations in the heart-valve tissue of RHD and MXD patients were identified and characterized, with controls from cadaveric organ donors. Proteins were separated by two-dimensional (2D)-electrophoresis and identified by mass spectrometry… CONTINUE READING
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