Distinct MicroRNA Subcellular Size and Expression Patterns in Human Cancer Cells

@inproceedings{Chen2012DistinctMS,
  title={Distinct MicroRNA Subcellular Size and Expression Patterns in Human Cancer Cells},
  author={Beibei Chen and Bo Zhang and Huaxia Luo and Jiao Yuan and Geir Skogerb\o and Runsheng Chen},
  booktitle={International journal of cell biology},
  year={2012}
}
Introduction. Small noncoding RNAs have important regulatory functions in different cell pathways. It is believed that most of them mainly play role in gene post-transcriptional regulation in the cytoplasm. Recent evidence suggests miRNA and siRNA activity in the nucleus. Here, we show distinct genome-wide sub-cellular localization distribution profiles of small noncoding RNAs in human breast cancer cells. Methods. We separated breast cancer cell nuclei from cytoplasm, and identified small RNA… CONTINUE READING
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