Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II.

@article{Engel2018DistinctMO,
  title={Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II.},
  author={Christoph Engel and Simon Neyer and Patrick Cramer},
  journal={Annual review of biophysics},
  year={2018},
  volume={47},
  pages={
          425-446
        }
}
  • Christoph Engel, Simon Neyer, Patrick Cramer
  • Published in Annual review of biophysics 2018
  • Biology, Medicine
  • RNA polymerases I and II (Pol I and Pol II) are the eukaryotic enzymes that catalyze DNA-dependent synthesis of ribosomal RNA and messenger RNA, respectively. Recent work shows that the transcribing forms of both enzymes are similar and the fundamental mechanisms of RNA chain elongation are conserved. However, the mechanisms of transcription initiation and its regulation differ between Pol I and Pol II. Recent structural studies of Pol I complexes with transcription initiation factors provided… CONTINUE READING

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