Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma.

  title={Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma.},
  author={Ignacio Wistuba and Carmen Behrens and Jorge Albores-Saavedra and Ruby Delgado and Francisco Mart{\'i}n Orihuela L{\'o}pez and Adi F. Gazdar},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={9 10 Pt 1},
PURPOSE Signet ring cell colorectal carcinoma (SRCCC) represents a unique, infrequent, and highly malignant variant of colorectal cancer. To understand the pathogenesis of SRCCC, we investigated its molecular abnormalities and compared them with those of the usual type of colorectal adenocarcinoma. EXPERIMENTAL DESIGN Microdissected archival paraffin-embedded tissue from 16 SRCCCs and 27 non-SRCCCs was used to determine the frequency and pattern of mutation at codons 12, 13, and 61 of K-ras… CONTINUE READING


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