Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen

@article{Boehmer1979DistinctIG,
  title={Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen},
  author={Harald von Boehmer and Werner Haas},
  journal={The Journal of Experimental Medicine},
  year={1979},
  volume={150},
  pages={1134 - 1142}
}
The H-Y-specific cytotoxic T-cell response requires helper cells: cells from bone marrow chimeras B6 X CBA leads to B6, B6 X CBA leads to B10.A (5R), or B6 X CBA leads to CBA are each unable to respond to H-2k male cells. If, however, cells from B6 X CBA leads to B6 or B6 X CBA leads to B10.A (5R) chimeras are adoptively transferred together with cells from B6 X CBA leads to CBA chimeras, H-Y-specific CTL restricted to H-2k can be obtained. Thus, cells from B6 X CBA leads to B6 or B6 X CBA… CONTINUE READING

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