Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.

@article{Wu2008DistinctFA,
  title={Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.},
  author={Li Fang Wu and Joie A. Bernard-Trifilo and Y Lim and Steven Lim and Satyajit K. Mitra and Sean A. Uryu and M Chen and Catherine J Pallen and N-Kv Cheung and David P Mikolon and Ainhoa Mielgo and Dwayne G. Stupack and David D. Schlaepfer},
  journal={Oncogene},
  year={2008},
  volume={27 10},
  pages={1439-48}
}
Signals from fibronectin-binding integrins promote neural crest cell motility during development in part through protein-tyrosine kinase (PTK) activation. Neuroblastoma (NB) is a neural crest malignancy with high metastatic potential. We find that alpha4 and alpha5 integrins are present in late-stage NB tumors and cell lines derived thereof. To determine the signaling connections promoting either alpha4beta1- or alpha5beta1-initiated NB cell motility, pharmacological, dominant negative and… CONTINUE READING

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