Distinct Etiological Roles for Myocytes and Motor Neurons in a Mouse Model of Kennedy's Disease/Spinobulbar Muscular Atrophy.

@article{Ramzan2015DistinctER,
  title={Distinct Etiological Roles for Myocytes and Motor Neurons in a Mouse Model of Kennedy's Disease/Spinobulbar Muscular Atrophy.},
  author={Firyal Ramzan and Mike McPhail and Pengcheng Rao and Kaiguo Mo and Katherine Halievski and A Swift-Gallant and Lucia Mendoza-Viveros and Hai-Ying Mary Cheng and D Ashley Monks},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 16},
  pages={6444-51}
}
Polyglutamine (polyQ) expansion of the androgen receptor (AR) causes Kennedy's disease/spinobulbar muscular atrophy (KD/SBMA) through poorly defined cellular mechanisms. Although KD/SBMA has been thought of as a motor neuron disease, recent evidence indicates a key role for skeletal muscle. To resolve which early aspects of the disease can be caused by neurogenic or myogenic mechanisms, we made use of the tet-On and Cre-loxP genetic systems to selectively and acutely express polyQ AR in either… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 28 references

Inducible expression of cre recombinase in the retinal pigmented epithelium.

Investigative ophthalmology & visual science • 2008
View 2 Excerpts
Highly Influenced

Pioglitazone suppressesneuronalandmusculardegenerationcausedbypolyglutamine-expanded androgen receptors

IidaM, KatsunoM, +9 authors G Sobue
Hum Mol Genet 24:314–329 • 2015

New Routes to Therapy for Spinal and Bulbar Muscular Atrophy

Journal of Molecular Neuroscience • 2013
View 1 Excerpt

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