Distinct ERG rearrangement prevalence in prostate cancer: higher frequency in young age and in low PSA prostate cancer

@inproceedings{Schfer2013DistinctER,
  title={Distinct ERG rearrangement prevalence in prostate cancer: higher frequency in young age and in low PSA prostate cancer},
  author={Georg Sch{\"a}fer and J Mosquera and Reinhold Ramoner and Karen Sophia Park and A Romanel and Eberhard Steiner and Wolfgang Horninger and J Bektic and M Ladurner-Rennau and Mikael Rubin and Francesca Demichelis and Helmut Klocker},
  booktitle={Prostate Cancer and Prostatic Disease},
  year={2013}
}
Background:The TMPRSS2-ERG gene fusion resulting in ERG overexpression has been found in around 50% of prostate cancers (PCa) and is a very early event in tumorigenesis. Most studies have reported on selected surgical cohorts with inconsistent results. We hypothesized that ERG gene rearrangements impact tumor development and investigated the frequency of ERG overexpression in the context of clinicopathological tumor characteristics.Methods:ERG overexpression (ERG+ or ERG-) was determined by… CONTINUE READING

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Prostate Cancer and Prostatic Disease

  • G Schaefer
  • 2013

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