Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

@inproceedings{Ye2015DistinctEP,
  title={Distinct EMT programs control normal mammary stem cells and tumour-initiating cells},
  author={Xin Ye and Wai Leong Tam and Tsukasa Shibue and Yasemin Kaygusuz and Ferenc Reinhardt and Elinor Ng Eaton and Robert A Weinberg},
  booktitle={Nature},
  year={2015}
}
Tumour-initiating cells (TICs) are responsible for metastatic dissemination and clinical relapse in a variety of cancers. Analogies between TICs and normal tissue stem cells have led to the proposal that activation of the normal stem-cell program within a tissue serves as the major mechanism for generating TICs. Supporting this notion, we and others previously established that the Slug epithelial-to-mesenchymal transition-inducing transcription factor (EMT-TF), a member of the Snail family… CONTINUE READING