Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants.

@article{Giacomo2005DistinctDA,
  title={Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants.},
  author={Monica Di Giacomo and Marco Barchi and Fr{\'e}d{\'e}ric Baudat and Winfried Edelmann and Scott Keeney and Maria Jasin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 3},
  pages={737-42}
}
Defects in meiotic recombination in many organisms result in arrest because of activation of a meiotic checkpoint(s). The proximal defect that triggers this checkpoint in mammalian germ cells is not understood, but it has been suggested to involve either the presence of DNA damage in the form of unrepaired recombination intermediates or defects in homologous chromosome pairing and synapsis independent of DNA damage per se. To distinguish between these possibilities in the female germ line, we… CONTINUE READING
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