Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors.

Abstract

The mammalian sex-determining gene SRY (sex-determining region on Y chromosome) encodes a member of the high mobility group (HMG) family of regulatory proteins. The HMG domain of the SRY protein represents a DNA binding motif that displays rather unusually weak evolutionary conservation of amino acids between human and mouse sequences. Together with the… (More)

Topics

  • Presentations referencing similar topics