Distinct CpG methylation profiles characterize different clinical groups of neuroblastic tumors

  title={Distinct CpG methylation profiles characterize different clinical groups of neuroblastic tumors},
  author={Barbara Banelli and Ilaria Gelvi and Angela di Vinci and P. Scaruffi and Ida Casciano and Giorgio Allemanni and Stefano Bonassi and Gian Paolo Tonini and Massimo Romani},
The hypermethylation of CpG islands within gene promoter regions is an epigenetic phenomenon that is often, but not always, associated with the transcriptional silencing of downstream genes and contributes to carcinogenesis. We have determined the pattern of methylation of several genes involved in distinct biological pathways, including cell proliferation and apoptosis, in neuroblastoma and in the nonmalignant ganglioneuroma. The purpose of this work was to search for epigenetic signatures… CONTINUE READING


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