Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells.

@article{Darbon2000DistinctCA,
  title={Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells.},
  author={Josephine Darbon and Marie P{\'e}nary and Nathalie Escalas and Florence Casagrande and F Goubin-Gramatica and Caroline Baudouin and Bernard Ducommun},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 20},
  pages={15363-9}
}
Genistein, a natural isoflavone found in soybeans, exerts a number of biological actions suggesting that it may have a role in cancer prevention. We have previously shown that it potently inhibits OCM-1 melanoma cell proliferation by inducing a G(2) cell cycle arrest. Here we show that genistein exerts this effect by impairing the Cdc25C-dependent Tyr-15 dephosphorylation of Cdk1, as the overexpression of this phosphatase allows the cells to escape G(2) arrest and enter an abnormal chromatin… CONTINUE READING

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Genistein , a natural isoflavone found in soybeans , exerts a number of biological actions suggesting that it may have a role in cancer prevention .
Genistein , a natural isoflavone found in soybeans , exerts a number of biological actions suggesting that it may have a role in cancer prevention .
Genistein , a natural isoflavone found in soybeans , exerts a number of biological actions suggesting that it may have a role in cancer prevention .
Genistein , a natural isoflavone found in soybeans , exerts a number of biological actions suggesting that it may have a role in cancer prevention .
Cell ProliferationProcess includes biological processNegative Regulation of Cell Cycle
We have previously shown that it potently inhibits OCM-1 melanoma cell proliferation by inducing a G(2 ) cell cycle arrest .
Genistein , a natural isoflavone found in soybeans , exerts a number of biological actions suggesting that it may have a role in cancer prevention .
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