Distinct Ca2+-permeable Cation Currents Are Activated by Internal Ca2+-Store Depletion in RBL-2H3 Cells and Human Salivary Gland Cells, HSG and HSY

@article{Liu2004DistinctCC,
  title={Distinct Ca2+-permeable Cation Currents Are Activated by Internal Ca2+-Store Depletion in RBL-2H3 Cells and Human Salivary Gland Cells, HSG and HSY},
  author={Xibao Liu and Klaus Groschner and Indu S Ambudkar},
  journal={The Journal of Membrane Biology},
  year={2004},
  volume={200},
  pages={93-104}
}
Store-operated Ca2+ influx, suggested to be mediated via store-operated cation channel (SOC), is present in all cells. The molecular basis of SOC, and possible heterogeneity of these channels, are still a matter of controversy. Here we have compared the properties of SOC currents (I SOC) in human submandibular glands cells (HSG) and human parotid gland cells (HSY) with I CRAC (Ca2+ release-activated Ca2+ current) in RBL cells. Internal Ca2+ store-depletion with IP3 or thapsigargin activated… CONTINUE READING
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