Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

@inproceedings{Gerbe2011DistinctAA,
  title={Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium},
  author={François Gerbe and Johan H. van Es and Leila Makrini and B{\'e}n{\'e}dicte Brulin and Georg Mellitzer and Sylvie Robine and B{\'e}atrice Romagnolo and Noah F Shroyer and Jean-François Bourgaux and Christine Pignodel and Hans Clevers and Philippe Jay},
  booktitle={The Journal of cell biology},
  year={2011}
}
The unique morphology of tuft cells was first revealed by electron microscopy analyses in several endoderm-derived epithelia. Here, we explore the relationship of these cells with the other cell types of the intestinal epithelium and describe the first marker signature allowing their unambiguous identification. We demonstrate that although mature tuft cells express DCLK1, a putative marker of quiescent stem cells, they are post-mitotic, short lived, derive from Lgr5-expressing epithelial stem… CONTINUE READING
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