Distinct 5′ UTRs regulate XIAP expression under normal growth conditions and during cellular stress

@inproceedings{Riley2010Distinct5U,
  title={Distinct 5′ UTRs regulate XIAP expression under normal growth conditions and during cellular stress},
  author={Alura Riley and Lindsay E. Jordan and Martin Holcik},
  booktitle={Nucleic acids research},
  year={2010}
}
X-chromosome linked inhibitor of apoptosis, XIAP, is cellular caspase inhibitor and a key regulator of apoptosis. We and others have previously shown that XIAP expression is regulated primarily at the level of protein synthesis; the 5' untranslated region (UTR) of XIAP mRNA contains an Internal Ribosome Entry Site (IRES) that supports cap-independent expression of XIAP protein during conditions of pathophysiological stress, such as serum deprivation or gamma irradiation. Here, we show that XIAP… CONTINUE READING