Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin.

@article{Roche1996Distinct3D,
  title={Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin.},
  author={Jeffrey C. Roche and Ferenc Boldog and Mark Robinson and Lois Robinson and Marileila Varella-Garcia and Michael K. Swanton and Brook Waggoner and Richard Fishel and Wilbur Franklin and Robert M Gemmill and H. Drabkin},
  journal={Oncogene},
  year={1996},
  volume={12 6},
  pages={1289-97}
}
Loss of chromosome 3p is a critical event in the pathogenesis of lung cancer. Overlapping homozygous 3p21.3 deletions in lung cancer cell lines involving GNAI2 were characterized and found to involve a region of genomic instability. A new widely expressed Semaphorin, H.SemaIV, was isolated from the GNAI2 deletion region. Reduced H.SemaIV expression allowed identification of additional cell lines with submicroscopic or larger deletions of the locus which occurred in a heterogeneous manner. We… CONTINUE READING

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