Distinct α2 Na,K-ATPase membrane pools are differently involved in early skeletal muscle remodeling during disuse

@inproceedings{Kravtsova2016DistinctN,
  title={Distinct α2 Na,K-ATPase membrane pools are differently involved in early skeletal muscle remodeling during disuse},
  author={Violetta V Kravtsova and Alexey M Petrov and Vladimir V Matchkov and Elena V Bouzinova and Alexander N Vasiliev and Boubacar Benziane and Andrey Lvovich Zefirov and Alexander V Chibalin and Judith A Heiny and Igor I Krivoi},
  booktitle={The Journal of general physiology},
  year={2016}
}

• Violetta V Kravtsova, Alexey M Petrov, +7 authors Igor I Krivoi
• Published in The Journal of general physiology 2016
• DOI:10.1085/jgp.201511494

The Na,K-ATPase is essential for the contractile function of skeletal muscle, which expresses the α1 and α2 subunit isoforms of Na,K-ATPase. The α2 isozyme is predominant in adult skeletal muscles and makes a greater contribution in working compared with noncontracting muscles. Hindlimb suspension (HS) is a widely used model of muscle disuse that leads to progressive atrophy of postural skeletal muscles. This study examines the consequences of acute (6-12 h) HS on the functioning of the Na,K… CONTINUE READING

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