Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons


Many neurodegenerative diseases are characterized by the accumulation of insoluble protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer's disease and Lewy bodies composed of α-synuclein in Parkinson's disease. Moreover, different pathological proteins frequently codeposit in disease brains. To test whether aggregated… (More)
DOI: 10.1016/j.cell.2013.05.057


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