Distinct, tissue-specific regulation of vitamin D receptor in the intestine, kidney, and skin by dietary calcium and vitamin D.

@article{Zineb1998DistinctTR,
  title={Distinct, tissue-specific regulation of vitamin D receptor in the intestine, kidney, and skin by dietary calcium and vitamin D.},
  author={R Zineb and B Zhor and W Odile and Rousseau Marthe},
  journal={Endocrinology},
  year={1998},
  volume={139 4},
  pages={
          1844-52
        }
}
We studied the effects of vitamin D deficiency and its correction by vitamin D or calcium-lactose supplementation on vitamin D receptor (VDR) expression in skin keratinocytes, kidney, and duodenum of adult rats. VDR messenger RNA (mRNA) was assayed by Northern blot, and VDR protein was determined immunocytochemically. In addition, four subpopulations of keratinocytes were isolated, characterized for their stages of differentiation, and analyzed for VDR expression. Vitamin D deficiency decreased… 
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41 Citations
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41 Citations

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Citation Type

Immunohistochemical Demonstration of Vitamin D Receptor Distribution in Goat Intestines
TLDR
It is demonstrated that VDR distribution exhibits cell type-, segment- and location-specific patterns in the goat, which may serve as a basis for future experiments on the role of VDR in Ca metabolism.
Suppression of vitamin D receptor and induction of retinoid X receptor alpha expression during squamous differentiation of cultured keratinocytes.
TLDR
The results associate vitamin D receptor expression with undifferentiated, proliferating keratinocytes, whereas retinoid X receptor alpha expression appears to be related to the differentiated phenotype, which means proliferating and differentiating keratinocyte may be differentially targeted by active vitamin D metabolites.
1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin.
TLDR
The findings indicate that low VDR levels are maintained, in part, through ubiquitin/proteasome-mediated degradation and that lowVDR levels limit D3 signaling.
Regulation of parathyroid vitamin D receptor expression by extracellular calcium.
TLDR
It is shown that extracellular Ca regulates VDR expression by parathyroid cells independently of CTR and that by this mechanism hypocalcemia may prevent the feedback of CTR on the parathyroids.
Vitamin D receptor distribution in intestines of domesticated sheep Ovis ammon f. aries
TLDR
It is demonstrated that intestinal vitamin D receptor distribution patterns are segment‐specific and strongest immunoreactions correlate with highest intestinal calcium absorptive activities, as reported in literature.
Pilot Study on the Bioactivity of Vitamin D in the Skin after Oral Supplementation
TLDR
The findings of significant variability in the range of VDR and CYP24 expression across study samples represent an important consideration in studies evaluating the role of VD as a skin cancer chemopreventive agent.
Vitamin D(3) receptor ablation alters mammary gland morphogenesis.
TLDR
The results indicate that mammary glands from virgin Vdr knockout mice are heavier and exhibit enhanced growth, as evidenced by higher numbers of terminal end buds, greater ductal outgrowth and enhanced secondary branch points, compared with glands from age- and weight-matched wild-type mice.
PTH-1R responses to PTHrP and regulation by vitamin D in keratinocytes and adjacent fibroblasts
Vitamin D receptor amounts across different segments of the gastrointestinal tract in Brown Swiss and Holstein Frisean cows of different age.
TLDR
The results of this study indicate that VDR are highly expressed at the site of maximal intestinal calcium absorption, and may play a considerably more significant role during the peripartal period, when Ca homeostatic mechanisms are challenged because of tremendous Ca demand at the initiation of lactation.
Where is the vitamin D receptor?
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References

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TLDR
It is concluded that the action of vitamin D on the epidermis is associated with increases in both proliferation and differentiation of keratinocytes, and Vitamin D itself and its resulting action on calcium homeostasis appear to contribute to the observed effects.
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TLDR
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TLDR
The results of this study indicate that under physiologic conditions as during chronic dietary calcium restriction, increased intestinal vitamin D receptor content accompanies increased calcium active transport.
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  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1990
TLDR
It is demonstrated that serum calcium levels and vitamin D regulate 1,25-dihydroxyvitamin D3 receptor concentration in vivo in kidney and, on the other hand, vitamin D is unable to exert control of receptor levels in kidney under hypocalcemic conditions.
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TLDR
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TLDR
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TLDR
The effect of PTH on VDR regulation in vitro in ROS 17/2.8 cells and in vivo in male Holtzman rats is examined to suggest that PTH is a potent down-regulator of VDR and that P TH and 1,25(OH)2D3 have opposing effects on the expression of certain genes.
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TLDR
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