Distilling Pathophysiology from Complex Disease Genetics

@article{Chakravarti2013DistillingPF,
  title={Distilling Pathophysiology from Complex Disease Genetics},
  author={Aravinda Chakravarti and Andrew G. Clark and Vamsi K. Mootha},
  journal={Cell},
  year={2013},
  volume={155},
  pages={21-26}
}
Technologies for genome-wide sequence interrogation have dramatically improved our ability to identify loci associated with complex human disease. However, a chasm remains between correlations and causality that stems, in part, from a limiting theoretical framework derived from Mendelian genetics and an incomplete understanding of disease physiology. Here we propose a set of criteria, akin to Koch's postulates for infectious disease, for assigning causality between genetic variants and human… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 24 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

International IBD Genetics Consortium (IIBDGC)

  • L. Jostins, S. Ripke, +8 authors C.A
  • 2012
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…