Distant Precursors of Benzylisoquinoline Alkaloids and their Enzymatic Formation

@article{Rueffer1987DistantPO,
  title={Distant Precursors of Benzylisoquinoline Alkaloids and their Enzymatic Formation},
  author={M. Rueffer and M. Zenk},
  journal={Zeitschrift f{\"u}r Naturforschung C},
  year={1987},
  volume={42},
  pages={319 - 332}
}
The incorporation rates of labelled tyrosine, DOPA. tyramine. and dopamine have been investigated during the in vivo formation of the protoberberine alkaloid, jatrorrhizine, in callus cultures of Berberis canadensis. While tyrosine was equally well incorporated into both the isoquinoline (54%) and benzyl (46%) portions of the alkaloid, DOPA was almost exclusively (91%) transformed into the isoquinoline moiety. However, tyramine (25%) and to a lesser extent, dopamine (15%) were incorporated into… Expand
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