Distant Mimivirus relative with a larger genome highlights the fundamental features of Megaviridae

  title={Distant Mimivirus relative with a larger genome highlights the fundamental features of Megaviridae},
  author={Defne Arslan and Matthieu Legendre and Virginie Seltzer and Chantal Abergel and Jean-Michel Claverie},
  journal={Proceedings of the National Academy of Sciences},
  pages={17486 - 17491}
Mimivirus, a DNA virus infecting acanthamoeba, was for a long time the largest known virus both in terms of particle size and gene content. Its genome encodes 979 proteins, including the first four aminoacyl tRNA synthetases (ArgRS, CysRS, MetRS, and TyrRS) ever found outside of cellular organisms. The discovery that Mimivirus encoded trademark cellular functions prompted a wealth of theoretical studies revisiting the concept of virus and associated large DNA viruses with the emergence of early… 

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