Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast.

@article{Ricchetti2003DistanceFT,
  title={Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast.},
  author={Miria Ricchetti and Bernard Dujon and C. Fairhead},
  journal={Journal of molecular biology},
  year={2003},
  volume={328 4},
  pages={847-62}
}
Double strand break (DSB) repair plays an important role in chromosome evolution. We have investigated the fate of DSBs as a function of their location along the yeast chromosome XI, in a system where no conventional homologous recombination can occur. We report that the relative frequency of non-homologous endjoining (NHEJ), which is the exclusive mode of DSB repair in the internal chromosomal portion, decreases gradually towards the telomere, keeping the absolute frequency nearly constant… CONTINUE READING

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