Distance-Based Reconstruction of Tree Models for Oncogenesis

  title={Distance-Based Reconstruction of Tree Models for Oncogenesis},
  author={Richard Desper and Feng Jiang and Olli-P. Kallioniemi and Holger Moch and Christos H. Papadimitriou and Alejandro A. Sch{\"a}ffer},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={7 6},
Comparative genomic hybridization (CGH) is a laboratory method to measure gains and losses in the copy number of chromosomal regions in tumor cells. It is hypothesized that certain DNA gains and losses are related to cancer progression and that the patterns of these changes are relevant to the clinical consequences of the cancer. It is therefore of interest to develop models which predict the occurrence of these events, as well as techniques for learning such models from CGH data. We continue… CONTINUE READING