Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.

  title={Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.},
  author={Abedawn Ibrahim Khalaf and Roger D. Waigh and Allan J Drummond and Breffni Pringle and Ian McGroarty and Graham G. Skellern and Colin J. Suckling},
  journal={Journal of medicinal chemistry},
  volume={47 8},
Forty-eight heterocyclic amino acid trimers, analogues of distamycin, with a number of features that enhance lipophilicity are described. They contain alkyl or cycloalkyl groups larger than methyl; some are N-terminated by acetamide or methoxybenzamide and are C-terminated by dimethylaminopropyl or aliphatic heterocylic aminopropyl substituents. The ability of these compounds to bind principally to AT tracts of DNA has been evaluated using capillary zone electrophoresis. Significant… CONTINUE READING
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