Distal regulation of alternative splicing by splicing enhancer in equine beta-casein intron 1.

@article{Lenasi2006DistalRO,
  title={Distal regulation of alternative splicing by splicing enhancer in equine beta-casein intron 1.},
  author={Tina Lenasi and B Matija Peterlin and Peter Dov{\vc}},
  journal={RNA},
  year={2006},
  volume={12 3},
  pages={498-507}
}
The complexity of cotranscriptional splicing is reflected in the coordinated interplay between various cis-elements and transacting factors. In this report, we demonstrated that a cis-element in intron 1 of the equine beta-casein gene (intronic splicing enhancer 1, ISE1) increases the inclusion of all weak exons in its pre-mRNA. The ISE1 also functioned on a hybrid transcript, which was transcribed from the alpha-globin promoter, where it increased the inclusion of the human fibronectin EDA… CONTINUE READING
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