Distal-less homeobox 2 promotes the osteogenic differentiation potential of stem cells from apical papilla

@article{Qu2014DistallessH2,
  title={Distal-less homeobox 2 promotes the osteogenic differentiation potential of stem cells from apical papilla},
  author={Binbin Qu and Ousheng Liu and Xiaodan Fang and Haixia Zhang and Yuehong Wang and Hongzhi Quan and Jie Zhang and Jing Zhou and Jun Zuo and Jianxia Tang and Zhangui Tang},
  journal={Cell and Tissue Research},
  year={2014},
  volume={357},
  pages={133-143}
}
Dental tissue-derived mesenchymal stem cells (MSCs) are a reliable cell source for dental tissue regeneration. However, the molecular mechanisms underlying the directed differentiation of MSCs remain unclear; thus, their use is limited. The histone demethylase, lysine (K)-specific demethylase 4B (KDM4B), plays critical roles in the osteogenic commitment of MSCs by up-regulating distal-less homeobox 2 (DLX2) expression. The DLX2 gene is highly expressed in dental tissue-derived MSCs but the… CONTINUE READING
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