Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case–control study

@article{Schoof2009DistalAP,
  title={Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case–control study},
  author={Nils Schoof and F von Bonin and Inke R. K{\"o}nig and R M{\"o}ssner and Ullrich Krueger and K Reich and Carola Berking and Matthias Volkenandt and Anette-Gabriele Ziegler and Lars Boeckmann and Christiane Kuschal and K-M Thoms and Dieter Kube and Steffen Emmert},
  journal={Genes and Immunity},
  year={2009},
  volume={10},
  pages={586-590}
}
Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [−7400InDel, −6752AT (rs6676671), −3538AT (rs1800890), −1087AG (rs1800896), −597AC (rs1800872)] of the IL-10 5′-flanking region in a hospital-based case–control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with… CONTINUE READING

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